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GLP-1 medications require ongoing clinical monitoring and work as part of comprehensive treatment plans that include lifestyle modifications
Although direct clinical evidence of systemic NAD(P) depletion during GLP-1RA therapy is lacking, experimental and observational studies suggest that NAD turnover and micronutrient status can be altered in obesity and inflammatory states [83, 85], supporting the biological plausibility of substrate-sensitive vulnerability
[42] report lower maternal circulating values of leptin in women with gestational diabetes mellitus following daily supplementation with ALA (100 mg/8 weeks)
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