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A crowded field of next-generation contenders is also pushing forward: Amgen's AMG 133, Roche's GLP-1/GIP co-agonists, AstraZeneca's cotadutide, and Phase 2 candidates like HRS9531 and MariTide (a GLP-1 agonists plus GIP antagonist) are all showing early promise in obesity treatment

Launching a GLP-1-focused DTC sales platform could turn up the heat on their competition, especially Lilly with its similar consumer base

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Similarly to vitamin C, calcitriol can inhibit the NF-B pathway, which reduces the expression of genes linked to inflammation [335]

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