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Its active form, 1,25(OH)2D, regulates mucosal immunity, host defense, and inflammation by binding to the vitamin D receptor (VDR) in macrophages [73, 74], triggering the expression of the antimicrobial peptide cathelicidin (CAMP) (LL-37) and promoting autophagosomelysosome fusion and maturation [16, 75]

The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-beta

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Recently, it has been demonstrated that LSD1 inhibition can accomplish this by stimulating T-cell immunity in epithelial cancers (5, 6) and innate immunity in pediatric brain tumors (7)

However, the majority of research has been conducted in animals, and more comprehensive human studies are needed to establish its long-term safety