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In AP, necroptosis is mediated by receptor-interacting serine/threonine-protein kinases (RIPKs), particularly the RIPK1-RIPK3 axis and mixed lineage kinase domain-like protein (MLKL)

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151,152 H 2 S and cancer: beyond disturbed metabolism In addition to the energetic stimulus afforded by low H 2 S concentrations, the link between the adaptability of cancer cells to an evolving and challenging environment and enhanced H 2 S metabolism extends to adaptation to hypoxia, antioxidant capacity, neoangiogenesis, cell cycle regulation, apoptosis evasion and chemoresistance