semaglutide bmi md reviews GLP-1 for Medical Weight Loss Semaglutide from Bench to Bedside:

Glucagon-like peptide 1-related peptides increase nitric oxide effects to reduce platelet activation

Ongoing research into nutritional and exercise interventions, as well as novel pharmacological agents such as myostatin/activin pathway inhibitors (243) or agents targeting the apelin pathway (244) holds promise for preserving lean mass and improving overall health in patients undergoing treatment with GLP-1 and dual GIP/GLP-1 receptor agonists

It also works against what tirzepatide is trying to do

Semaglutide and Tirzepatide are medications designed to aid in weight loss and improve metabolic health

45 Based on the two above trials, hepatic impairment and renal impairment should not affect dose recommendations for oral semaglutide, which is similar to semaglutide administered subcutaneously