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A 2023 observational analysis published in the Annals of the Rheumatic Diseases found that patients with inflammatory arthritis who used GLP-1 receptor agonists had lower rates of cardiovascular events, which is notable because cardiovascular disease is a leading cause of death in RA patients

In endothelial cells (ECs), copper overload disrupts mitochondrial dynamics, increases fission and ROS production, and ultimately leads to cell death [34] In cardiomyocytes, copper promotes hypertrophy and inflammation [35], disrupts fatty acid and lipid metabolism, upregulates autophagy-associated proteins and genes, and impedes calcium ion uptake by the sarcoplasmic reticulum, thereby inhibiting myocardial contractility [36]

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Berberine is extracted from plants like barberry, goldenseal, and Oregon grape