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These enzymes are responsible for the metabolism of B(a)P to a carcinogenic compound BPDE [benzo(a)pyrene-7,8-diol-9,10-epoxide], and CYP induction is associated with damage to the DNA of spermatozoa and ROS overexpression ( Overall, the results presented here show how the use of Modified Risk Tobacco Products can induce some of the same toxicological outcomes triggered by tobacco smoking, although less marked

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doi: 10.3945/ajcn.117.157834, 46

Research Background Research on DSIP has explored its effects on sleep spindle activity, delta wave amplitude, and cortisol modulation