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Finally this review will highlight future directions in IBS therapy research, including identification of new molecular targets, application of 3-D gut model, gut-on-a-chip and personalized therapy

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This work was supported by grants from the Postgraduate Education Innovation program of Shanxi Province (2024SJ155, YW), the central government guiding local funds for scientific and technological development (YDZJSX20231A062, CX), scientific and technological achievements transformation guidance project of Shanxi Province (202204021301067, CX), the National Natural Science Foundation of China (82350710800, 82374470, JX), National Key R&D Program of China (2024YFA0919200, JX), Shenzhen Science and Technology Program (KCXFZ20240903094059020, JX), and Shenzhen Medical Research Fund (B2302005, JX)

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Association of p16 gene methylation with prostate cancer risk: a meta-analysis