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Moreover, data from post-marketing surveillance and large population-based studies, especially from the US, are limited

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While it has been postulated that these two actions are inextricably linked more recent data shows they can indeed be divorced which opens the opportunity for tailored pharmacology that provide food intake reduction without the adverse events typically associated with GLP-1R agonism

Stedman Distinguished Professor of Nutrition in the School of Medicine and director of the DMPI

This increase in visceral abdominal fat is linked with increased inflammation and free fatty acids that impair metabolic function, and is also linked to a higher risk of cardiovascular disease and metabolic syndrome