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In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye in an ear meets a long standing need for suitable testing methods that are applicable to the development of intratympanic otic formulations or compositions suitable for human use

There were 162 differentially expressed genes (DEGs) at 3 months and only 54 DEGs at 8 months in iSPN + mut compared with iSPN + wt (Fig

Carrillo-Sepulveda, M

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6 Oxidative stress is considered a major driver of age-related cataracts, and excess oxygen and reactive oxygen byproducts have been linked to increased cataract risk