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Additionally, disruptions in the balance between excitatory neurotransmitters like glutamate and inhibitory neurotransmitters like gamma-aminobutyric acid (GABA) can further exacerbate depressive symptoms

Androgens are produced by the innermost zona reticularis, which aids in the development of secondary sexual characteristics (13) ( Figure 1 )

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Other studies have shown that ROS production in response to glutamine deprivation increases the expression of p53-dependent genes ( Gadd45a, Cdkn1, and Sestrin2 ) via B55 or IKK 124,125