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TNF- Inhibitor Therapy and Its Clinical Impact With infliximab as the first biologic agent approved for the therapy of CD in 1998, TNF- inhibitors have a long history regarding the treatment of chronic inflammatory diseases

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There is an increase in intracellular calcium in beta cells due to the depolarization caused by this inhibition, which leads to the release of insulin from the beta cells (Luzi L and Pozza G 1997)