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GLP-1 and GIP are gut-derived incretin hormones that augment glucose-stimulated insulin secretion and have been shown to have important roles in weight regulation

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In the primary Phase 2 clinical trial published in the New England Journal of Medicine (Jastreboff et al., 2023), retatrutide was studied across several dose levels, including: 1 mg (low dose) 4 mg (mid dose) 8 mg (higher dose) 12 mg (highest dose) These doses were administered as once-weekly subcutaneous injections

Generally mixed type of injuries, involving both hepatocellular and cholestatic mechanisms, occurs [70]