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Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems

It activates the SIRT1/peroxisome proliferator-activated receptor-gamma coactivator 1 (PGC-1) pathway to promote mitochondrial biogenesis, regulate mitochondrial homeostasis, and inhibit the high mobility group protein (HMGB)1/TLR4/p38/extracellular regulated protein kinases (ERK)1/2 pathway to reduce inflammatory responses in CIA mice (259)

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This will be helpful for future research directions for promoting sustainable agricultural development