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A recent randomized and double-blind trial revealed that, for adults with poorly controlled T2DM, oral semaglutide at total doses of 25 mg and 50 mg was more effective than the 14-mg total dose in reducing HbA1c and body weight (33)

It has been shown that GLP-1/the GLP-1R agonist exendin-4 increases GABA A R-mediated tonic currents through GLP-1R activation in rat hippocampal CA3 pyramidal neurons [14], but no data concerning the regulation of GABARs of retinal neurons by GLP-1/GLP-1R agonists are now available

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The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)