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Under pathological conditions of TBI, the MCU protein on the inner mitochondrial membrane can transport a large amount of calcium ions into the mitochondria, disrupting the normal function of the mitochondria (Peng and Jou, 2010

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Ferroptosis is a newly discovered apoptotic process characterized by intracellular free iron excess, which mediates Fenton reaction and eventually leads to lipid peroxidation in the cell membrane leading to cell death

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