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Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart or blood vessel disease, heart failure, blood circulation problems, anemia, metabolic acidosis, an adrenal gland or pituitary gland disorder, vitamin B12 deficiency, or had a heart attack

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The most cited concern is the same as for GH therapy: IGF-1 elevation has a complex relationship with cancer risk in epidemiological studies, with some analyses suggesting higher IGF-1 correlates with increased risk of certain cancers, while others find the opposite in older populations where IGF-1 is already low [16]

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