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(2022) 14:e27335

Major barriers to the clinical use of gene therapy, however, include transfection efficiency, the creation of long-term effects, the difficulty of controlling cell proliferation, ectopic transfection, disease transmission, patient-specific dose responses, immune reactions against viral proteins, possible side effects, and ethical issues [87, 88]

doi: 10.1155/2015/652738 69 GilbertRECooperME

Another study highlighted the metabolomic changes associated with vitamin B12 deficiency and repletion, showing improvements in markers of mitochondrial function, myelin integrity, and peripheral nerve function after vitamin B12 injections

Ottawa, ON: Canadian Pharmacists Association