Gclc f/f mice 27 were crossed with the MMTV-PYMT (The Jackson Laboratory, 022974) 61 and Rosa26 creERT2 (The Jackson Laboratory, 008463) 62 mouse strains
For instance, glutamine restriction impaired the growth and differentiation of B and T cells (147) and diminished antigen presentation and phagocytotic capacities of macrophages and neutrophils (148, 149)
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These cells carry distinct chromatin and DNA methylation patterns, so important cell-specific changes can easily be obscured 186,187
To fill this void, many people turn to glutathione supplements