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For researchers who need pure GLP-1 agonism without confounding from GIP and glucagon pathways, semaglutide remains the better choice

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It slows gastric emptying, enhances satiety, and reduces hunger signals in the brain, leading to reduced caloric intake and sustained weight loss

The critical distinction is reversibility and risk profile: Retatrutide is a weekly injection with temporary, manageable side effects versus a permanent surgical intervention with non-trivial operative risk