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10.1016/j.urology.2006.10.008 Urology 27 HuangJ.PlassC.GerhauserC

Its often triggered by sun exposure, hormonal imbalance, pregnancy, or stress, and can worsen under Pakistans harsh UV rays and pollution

PI3K/AKT signaling is stimulated by growth factors like IGF-1 and prevents the pro-apoptotic transcription factors, including FOXO1, thereby lifting the suppression of steroidogenic genes and increasing progesterone production ( Figure 5 )