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Key data point: in SURMOUNT-1, tirzepatides dual GIP/GLP-1 action produced about 21 percent mean weight loss at 72 weeks

The subjects who took Zepbound had more weight loss than those who were given a placebo, and having the other conditions did not make a difference in that weight loss

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Headache: Some people report mild to moderate headaches when beginning treatment

This inhibition results in a lipid overload state, where non-oxidized fatty acids are diverted into pathways generating more ceramides, perpetuating a self-amplifying cycle of metabolic stress and dysfunction (Serra et al., 2013)