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MC1R (melanocortin 1 receptor) is a GPCR on melanocytes that controls melanin production

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study Nature Medicine 2019;25(7):1096-1103 doi:10.1038/s41591-019-0495-2 (Human trial, small) Suenaert P, Segers A, Rymenans L, et al

Mmut p.L690Ins/p.L690Ins mice treated with AAV8.CB7.hMMUT also exhibited a significant reduction in plasma methylmalonic acid levels at approximately 1.5 months of age, 5 weeks following injection of the virus (Supplemental Figure 4C)

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