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Patients reporting intolerable symptoms at therapeutic doses should not proceed to higher doses, even if weight loss has plateaued
Kidney Problems Some patients, particularly those prone to dehydration due to vomiting or diarrhea, may experience kidney issues
Notably, AHCY is the only reversible enzyme in the methionine cycle and as such is a key regulator of the SAM to SAH molar ratio, commonly referred to as the methylation index or indicator of methylation capacity. [67] When SAH and homocysteine concentrations increase faster than methionine regeneration, SAM utilizing enzymes are inhibited by SAH and the SAM concentrations then act in a feed-forward mechanism to allosterically activate the B6-dependent cystathionine beta-synthase (CBS) which metabolizes homocysteine through the transsulfuration pathway and allows the methionine cycle to continue [68,69]
Data 92 LauritzenL.HansenH
However, they are not miracle cures and should always be part of a medically guided treatment plan
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