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4A, C, and D)

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The follicle stages were classified according to the Pedersen criteria 14,15

Manufacturing process of reduced glutathione or the sodium salt thereof according to claims 1 to 6, which comprises: a) production of glutathione from a microbial biomass, preferably a yeast, b) optionally, lysis of said biomass under acidic conditions, c) separation of the biomass and the fragments thereof from the glutathione- containing aqueous solution, d) purification of the aqueous solution of glutathione by resin chromatography, in one or more steps, under controlled temperature and pH conditions, using aqueous eluents only, e) optionally, decolourisation of the aqueous solution of glutathione with charcoal, diatomaceous earth or other decolourising agents, f) spray-drying of the purified or partially purified glutathione solution