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its reactivation in somatic cells could theoretically extend replicative lifespan by maintaining telomere length

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Cell Culture, transfections and siRNA knock-down Min6 cells (AddexBio) were cultured in DMEM (Gibco) with 15% fetal bovine serum, 100 mg/ml penicillin-streptomycin and 55 mM -mercaptoethanol (Sigma, M6250)

Both medications reduce appetite through different pathways, and their combined effect might lead to inadequate caloric and nutrient intake, potentially causing muscle loss, vitamin deficiencies, or metabolic complications