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The decrease in circulating melatonin levels over the course of a persons lifetime, which coincides with a more general decline in many circadian rhythms as people get older, is a compelling indicator that melatonin, even at physiological levels, may have an important role to play in this process

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The tripeptide GHK enhances brain level of BDNF in aged mice and AbetaPP/PS1 mice and improves learning and memory in aged mice

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[3] Two research-context points follow from this