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This is precisely what one might expect to see if GPX1 is a protease substrate , because its cleavage would produce two fragments that would necessarily have reduced affinity to the enzyme relative to GPX1

86 In this model, CLP induced PMN infiltration in the peritoneal cavity, the site of infection, as well as in the lung, ultimately resulting in lung injury and death, with a concomitant decrease in endogenous GSH