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The benefits decreased with the advancement of metabolic conditions, as seen in patients with diabetes, cardiovascular diseases, or kidney failure

The increasing A aggregation also led to the release of nitric oxide, reactive oxygen species (ROS), and proinflammatory cytokines which are factors that may contribute to neuronal death ( APOE4 difference from other APOE isoforms Apolipoprotein E (APOE) is a protein that transports cholesterol and lipids

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This modulation can lead to decreased inflammation in tissues

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