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In the STEP trials, participants receiving semaglutide lost 9.2% to 17.4% of baseline body weight over 68 weeks, with most not following a structured exercise program

Long-term use requires careful monitoring for metabolic complications including diabetes and osteoporosis

The impact on B cells remains undetermined

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Notably, 2 randomized trials of detemir use compared with NPH in women with type 1 diabetes showed a lowering of FBG, but similar A1C, maternal hypoglycemia, and other maternal and fetal outcomes (140)