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showed that under combined hypoxia and TGF-1 stimulation, paricalcitol inhibits Smad2 phosphorylation, regulates hypoxia-inducible factor-1 (HIF-1) signaling, and reduces oxidative stress, thereby blocking the transition of pericytes into myofibroblasts (38)

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The study was conducted in the context of describing the biochemical activities of the multifunctional protein sirtuin 1, which is involved in circadian rhythm regulation as well as in many other metabolic functions

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