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It can be used as monotherapy when metformin is inappropriate, or in combination with other glucose-lowering medicinal products, including insulin, when these alone are inadequate

Davidson et al., 1977) or with the NE precursor L-Threo-3,4-dihydroxyphenylserine (L-threo-DOPS) (Yamamoto et al., 1986

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Semaglutide, for example, has also been approved for T2DM in tablet form but this oral peptide formulation must be taken on an empty stomach first thing in the morning, with food and water restricted for 30 minutes afterwards