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Abdul-Rahim HF, Husseini A, Bjertness E, Giacaman R, Gordon NH, Jervell J

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Epidemiological Studies A cross-sectional study discovered that older individuals with higher lutein concentrations in plasma have a reduced risk of age-related cataracts (RR = 0.58, 95% CI = 0.350.98, p = 0.041) [21]

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The honest answer is that DSIPs own pharmacology a plasma half-life measured in minutes in every animal species tested, and reported effects that were explicitly not dose-proportional is the reason no consensus dose ever emerged, and why the numbers circulating online bear little resemblance to the numbers in the studies