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Always refer to the label on the product to confirm the beyond-use date assigned to that specific preparation

Maintaining Weight Loss After Semaglutide: Long-Term Expectations Weight regain occurs in approximately 50% of patients within 12 months after stopping semaglutide, highlighting that sustained medication use represents the standard long-term approach for maintaining benefits

Journal of Immunology Research , 2021 (1), 7552546

A head-to-head clinical trial (SURMOUNT-5) published in The New England Journal of Medicine in 2025 also demonstrated the superiority of tirzepatide over semaglutide