Significant and meaningful, but perhaps not transformative for someone who needs to lose 80 or 100 pounds to reach a healthy weight
Peer-reviewed clinical trials Wilding JPH et al., STEP-1, NEJM 2021, PMID 33567185 : semaglutide 2,4 mg, weight loss -14,9% at 68 weeks
In addition, diabetes alters the antioxidant capacity of the heart, which is shown in the decreases in enzymatic (catalase, superoxide dismutase, glutathione peroxidase etc.) and non-enzymatic antioxidant defenses (vitamins A, E, or C) [140]
But recently a pill version was released, and Aronne believes the pill is going to be a popular method to take the drug
The inability of antioxidant systems, such as GPX4-dependent pathways, to counteract ROS amplifies ferroptotic damage (90)