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Zhang C, Candia AA, Sferruzzi-Perri AN

In MC4R -deficient individuals, FTO risk allele carriers have significantly reduced weight loss efficacy after semaglutide treatment compared with those with normal genotypes, and the rate of weight regain in the later stage of treatment is significantly higher [79]

Acknowledgments During the preparation of this manuscript, the authors used Google Gemini (Version 3) for assistance in generating conceptual figure layouts

Grace, R

Semaglutide has a strong clinical track record, making it one of the most effective options available for adults who have struggled to lose weight through diet alone