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On the other hand, the RBC pre-loading of recombinant immunophilins permits increasing the binding and transport of immunosuppressive drugs

In parallel, vectors consisting of adeno-associated viruses (AAV) provide a gene therapy-based approach for sustained, localized expression of neurotrophic factors in target brain regions [243, 244]

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Despite its rarity, ALS represents the most prevalent and studied motor neuron disease, with clinical onset and progression varying significantly across individuals