While formal evidence remains in development, the mechanistic rationale is compelling: sustained, gentle GLP-1 receptor activation may favorably influence glucose metabolism, cardiovascular integrity, and neuroprotection, all while maintaining tolerability and adherence
Methods: A comprehensive literature search was performed across multiple medical databases, including Embase, Medline, and Cochrane to look for English articles on interventions with SGLT2 inhibitors, GLP-1, and dual gastric inhibitory polypeptide/GLP-1 receptor agonists in people living with sleep apnea and overweight or obesity
Recently, in addition to the central maintenance of food intake, GLP-1R signaling has begun to be considered in the context of the regulation of the stress response, as it is indicated that it can activate both the hypothalamicpituitaryadrenal (HPA) axis as well as the sympathetic nervous system [15, 16]
She said she doesn't like Wegovy as much as her old medication, but she now feels lucky to be on any GLP-1
Studies have shown that GLP-1 can be used for treatment of cardiac diseases, possibly independent of their effect in obesity [33] (Fig
