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These include primary mitochondrial diseases, multiple acyl-CoA dehydrogenase deficiency (MADD), BrownVialettoVan Laere syndrome (BVVL), as well as more prevalent conditions such as migraine, Parkinsons disease, multiple sclerosis, and cognitive impairment (48)

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549 This crosstalk ensures that when the chaperone system is overwhelmed, autophagy can step in to clear the accumulating toxic proteins

By modulating the intestinal microbiota, resveratrol affects the GBA, contributing to the regulation of insulin sensitivity and mitochondrial biogenesis through the activation of Sirt1

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