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The rapid symptom improvement described in a BN case report using liraglutide, with remission occurring within two weeks and maintained for five years [57], may compatible with a possible replacement-like mechanism, although this interpretation remains speculative and requires confirmation in controlled studies

Abbreviations AMLN : Amylin liver nonalcoholic steatohepatitis ER : Endoplasmic reticulum FFA : free fatty acids FFD : Fast-food diet GAN : Gubra amylin GLP-1RAs : Glucagon-like peptide-1 receptor agonists HFCC : High-fat high-cholesterol high-cholic acid HFCC-CDX : High-fat high-cholesterol high-cholic acid diet with hydroxypropyl--cyclodextrin in drinking water HFD : High-fat diet HTFD : High-trans-fat high-fructose high-cholesterol diet MCD : Methionine-choline deficient NAFLD : Nonalcoholic fatty liver disease NLRP3 : Nod-like receptor protein amilypyrin domain containing 3 ROS : Reactive oxygen species SD : Sprague-Dawley TNF- : Tumor necrosis factor- References Henry L, Paik J, Younossi ZM (2022) Review article: the epidemiologic burden of non-alcoholic fatty liver disease across the world

Human / Clinical Evidence: What We Know Now we move from what could happen, to what seems to happen in people

Example Impacts: Kidney/Cardiovascular/Diabetes Drugs and Device Makers: A reduction in disease burden is likely to have a negative impact on demand for drugs, devices, software and services related to these conditions

95% CI, 1.61-1.71) compared to those with MASLD