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This is mainly due to the fact that research has traditionally focused on well-known stress molecules like SA or JA, or simply measured the activity of selected redox enzymes

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Some biomarkers are usually increased relatively quickly after pollution treatment like: pH, lactic acid content , sebum production and secretion, advanced glycation end products (AGE), malondialdehyde (MDA) and squalene monohydroperoxide (SQOOH) (marker for lipid peroxidation), protein oxidation, cellular oxidative stress levels (radicals), Interleukin-1a (IL), IL-6

The primary enzyme responsible for breaking down histamine from food sources is diamine oxidase (DAO), which acts in the gut