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Clinical trials show that diarrhea-related symptoms typically emerge within the first 2 to 4 weeks of treatment initiation and resolve for most patients within 8 to 12 weeks as the body adapts to the medication
Given that both ME/CFS patients and GWS models exhibit elevated levels of oxidative stress, the symptom improvement observed with oxaloacetate treatment may be attributable to its capacity to reduce oxidative stress (Gottschalk et al., 2022
Around the same time, I think you remember that all of pharma was interested in obesity in the early 90s, everyone wanted to do diabetes as well as obesity, but they were separate teams and they all wanted to do small molecules, but it just happens to be so that the best idea we could find at that time was actually GLP-1, because we actually had clinical data relatively early that GLP-1 was a really good candidate as a treatment for diabetes because of the glucose sensitivity of the actions
Van Der Veen JN, Kennelly JP, Wan S, Vance JE, Vance DE, Jacobs RL
They prepare customized medications for individual patients or, in the case of outsourcing facilities, compound medications under specific statutory requirements
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