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For the second primary endpoint of percentage change in body weight from baseline to 52 weeks, semaglutide had a consistent beneficial effect across diuretic use categories

The SURMOUNT-4 trial with tirzepatide showed that participants who continued the medication lost an additional 5.5% of their body weight, while those who switched to a placebo regained 14%

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Compounded semaglutide can last up to 60 days at room temperature and typically remains effective for 28 days once opened if refrigerated