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In EAE mice, adoptive transfer of itaconate-treated, Th17-polarized T cells significantly ameliorated disease severity (173), highlighting the potential of targeting metabolic pathways to modulate the Th17/Treg balance in autoimmune neuroinflammation

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It took about 36 hours for it to work, but then my appetite dropped off a cliff for 7-10 days

The concurrent inhibition of MEK (trametinib) and glutamine metabolism (V-9302) enhances antitumor efficacy by orchestrating the FOXO3a/FOXM1 axis and autophagy, leading to pyroptosis and cell cycle arrest (135)