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This decline correlates with increases in visceral fat, decreases in lean mass, reduced bone density, and skin thinning

"That's why this discussion is so important and why the FDA's authority here is an important one to exercise appropriately with optimal outside advice," he says.

Potential pancreatitis risk : As with other GLP-1-based therapies, there is a theoretical concern regarding pancreatitis, though causality has not been firmly established in trials to date

Animal studies show protection against myocardial infarction damage, arrhythmia prevention, and a unique ability to activate collateral blood vessel pathways

Acute injuries may require 4-6 weeks, while chronic conditions or gut health protocols may benefit from longer courses of 8-12 weeks or more