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Due to the higher number of participants, this study was greatly weighted and influenced the overall results, so removing of mentioned study in sensitivity analysis changed the increasing effects of NAC on the FSH levels

received a Portuguese Foundation for Science and Technology (SFRH/BD/52036/2012) scholarship

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Change history 15 February 2025 A Correction to this paper has been published: Abbreviations AAV: Adeno-associated virus ACEA: Arachidonoyl 2-chloroethylamide AEA: Anandamide 2-AG: 2-Arachidonoylglycerol BiP: Binding-immunoglobulin protein CBD: Cannabidiol CB1R: Cannabinoid type 1 receptor CB2R: Cannabinoid type 2 receptor CNR1KD: Cannabinoid receptor 1 knockdown CXCL10: C-X-C motif chemokine ligand 10 DAGL: Diacylglycerol lipase ECS: Endocannabinoid system ER: Endoplasmic reticulum GSIS: Glucose-stimulated insulin secretion IEQ: Islets equivalent MAGL: Monoacylglycerol lipase PBMC: Peripheral blood mononuclear cell RNS: Reactive nitrogen species ROS: Reactive oxygen species References International Diabetes Federation IDF Diabetes Atlas

Nutrition Tips for Success To ensure success and minimize the chances of negative side effects while taking Semaglutide, follow these dietary guidelines: Protein Intake: Women: Aim for approximately 80-120 grams of protein per day Men: Aim for approximately 100-150 grams of protein per day Water Intake: Try to consume about -1 gallon of water daily