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Research has shown that various oligosaccharides can counteract imbalances in the microbiota by encouraging the growth of Lactobacilli , reducing Proteobacteria populations, and lowering the Firmicutes / Bacteroidetes ratio in diet-induced obese rodents [93,94,95]

141 The extent to which this allosteric activation model characterizes other metal-sensing MarR proteins yet to be characterized is unknown

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How much intact complex ultimately reaches the skin has not been quantified in humans