Reductions in inflammatory markers observed in clinical trials are secondary outcomes, not primary therapeutic targets
Patients should discuss their individual risk factors with healthcare providers, and monitoring is recommended as a precaution
What matters is whether the pattern is new, persistent, or paired with other symptoms like severe pain, blood in stool, or dehydration
However, it is impor-tant to note that the occurrence of liver damage with paracetamol and its severity is a function not only of the dose but also of various host factors (Pirmohamed, Kitteringham and Park)
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