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Absorption, distribution, metabolism, and excretion of [(14)C]-Sotorasib in rats and dogs: interspecies differences in absorption, protein conjugation and metabolism

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Among the genes identified is a nonheme, -ketoglutarate-dependent oxygenase that catalyzes oxidative C-C bond formation that converts the intermediate ()-yatein ( 326 ) to the fused 5-6-6-5 tetracyclic framework in ()-deoxypodophyllotoxin ( 327 ) that is the characteristic core of podophyllotoxins and etoposide

66, 233-42, 2004) are cheaper than synthesis, and also produce the product in an optically pure form