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Tian R., Abarientos A., Hong J., et al., GenomeWide CRISPRi/A Screens In Human Neurons Link Lysosomal Failure to Ferroptosis, Nature Neuroscience 24 (2021): 10201034

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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

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